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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLL All Species: 10.91
Human Site: S222 Identified Species: 21.82
UniProt: Q9UGP5 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UGP5 NP_037406.1 575 63482 S222 I S G H Y P T S L E G D C E P
Chimpanzee Pan troglodytes XP_507992 575 63394 S222 I S G H Y P T S L E G D C E P
Rhesus Macaque Macaca mulatta XP_001110483 575 63575 S222 I S G H Y P A S L E G D C D P
Dog Lupus familis XP_850651 576 63314 H223 I S G H Y S T H P E G D D D P
Cat Felis silvestris
Mouse Mus musculus Q9QXE2 573 62924 P220 I T G H Y P T P P E E D G G P
Rat Rattus norvegicus Q5RKI3 573 62383 P220 I S G H Y P T P P G E D G G P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511409 1156 126349 P236 S G R Y P R P P G E E D E P D
Chicken Gallus gallus XP_001232209 575 63775 S222 G H Y P V K L S E E T S D S S
Frog Xenopus laevis O57383 334 38275
Zebra Danio Brachydanio rerio Q6DRD3 336 38547
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785226 410 45521 D69 A V V K P A I D D Q T T H V I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_172522 529 59569 S186 G I A E T P T S P Q S E S T S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97 85.4 N.A. 82.4 82.4 N.A. 33.8 66.7 22 21.5 N.A. N.A. N.A. N.A. 20
Protein Similarity: 100 99.6 98.4 91.3 N.A. 88.3 88.8 N.A. 40.2 78 36.7 36.1 N.A. N.A. N.A. N.A. 37.7
P-Site Identity: 100 100 86.6 66.6 N.A. 60 60 N.A. 13.3 13.3 0 0 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 93.3 73.3 N.A. 66.6 60 N.A. 20 13.3 0 0 N.A. N.A. N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. 29.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 47.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 9 0 0 9 9 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 25 0 0 % C
% Asp: 0 0 0 0 0 0 0 9 9 0 0 59 17 17 9 % D
% Glu: 0 0 0 9 0 0 0 0 9 59 25 9 9 17 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 17 9 50 0 0 0 0 0 9 9 34 0 17 17 0 % G
% His: 0 9 0 50 0 0 0 9 0 0 0 0 9 0 0 % H
% Ile: 50 9 0 0 0 0 9 0 0 0 0 0 0 0 9 % I
% Lys: 0 0 0 9 0 9 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 9 0 25 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 9 17 50 9 25 34 0 0 0 0 9 50 % P
% Gln: 0 0 0 0 0 0 0 0 0 17 0 0 0 0 0 % Q
% Arg: 0 0 9 0 0 9 0 0 0 0 0 0 0 0 0 % R
% Ser: 9 42 0 0 0 9 0 42 0 0 9 9 9 9 17 % S
% Thr: 0 9 0 0 9 0 50 0 0 0 17 9 0 9 0 % T
% Val: 0 9 9 0 9 0 0 0 0 0 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 9 50 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _